Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Twsg1tm1Ecan
Name:	twisted gastrulation BMP signaling modulator 1; targeted mutation 1, Ernesto Canalis
MGI ID:	MGI:3802605
Synonyms:	Twsg1LacZ
Gene:	Twsg1  Location: Chr17:66230060-66258198 bp, - strand  Genetic Position: Chr17, 35.26 cM
Alliance:	Twsg1tm1Ecan page

Germline Transmission:	Earliest citation of germline transmission: J:137597
Parent Cell Line:	F1H4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NTac)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced with a lacZ and floxed neo cassette. The absence of transcript was confirmed by northern blot analysis of 4 week old total RNA extracts. (J:137597)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Twsg1 Mutation:	20 strains or lines available

Original:	J:137597 Gazzerro E, et al., Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. Bone. 2006 Dec;39(6):1252-60
All:	4 reference(s)