Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Comttm1Mkae
Name:	catechol-O-methyltransferase; targeted mutation 1, Mikko Kaenmaki
MGI ID:	MGI:4830700
Synonyms:	S-COMT
Gene:	Comt  Location: Chr16:18225636-18245602 bp, - strand  Genetic Position: Chr16, 11.4 cM
Alliance:	Comttm1Mkae page

Germline Transmission:	Earliest citation of germline transmission: J:164057
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A mutation of the methionine coding start codon (ATG) for S-COMT to threonine (ACC), corresponding to 'ATG' position +30 in exon2 of Comt gene and a floxed neo cassette in intron 4 were introduced by homologous recombination. The selection cassette was removed by cre mediated recombination. The S-COMT (24 kDa) isoform was absent on western blots of liver extracts, while the MB-COMT was detected. (J:164057)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Comt Mutation:	23 strains or lines available

Original:	J:164057 Kaenmaki M, et al., Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol. 2009 Dec;158(8):1884-94
All:	2 reference(s)