Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stat2p117
Name:	signal transducer and activator of transcription 2; pedigree p117
MGI ID:	MGI:4830698
Gene:	Stat2  Location: Chr10:128106428-128128718 bp, + strand  Genetic Position: Chr10, 76.5 cM
Alliance:	Stat2p117 page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) (Hypomorph) Mutation:    Single point mutation   Mutation details: A T to A point mutation in the 5' splice site of the STAT2 intron 4-5 results in the cryptic splicing of Stat2 mRNA by using a new 5' splice site GU located three nucleotides downstream of the mutation. The alternative splicing caused frame-shift and created stop codons which left out critical domains of STAT2 protein including DNA binding domain, Src homology 2 and transactivation domains. The mutation is hypomorphic as some wild-type protein is still detectable. (J:164049) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat2 Mutation:	35 strains or lines available

Original:	J:164049 Chen LS, et al., STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. J Biomed Sci. 2009;16:22
All:	1 reference(s)