About   Help   FAQ
Acetm8.1Keb
Targeted Allele Detail
Summary
Symbol: Acetm8.1Keb
Name: angiotensin I converting enzyme; targeted mutation 8.1, Kenneth E Bernstein
MGI ID: MGI:4830151
Synonyms: ACE13
Gene: Ace  Location: Chr11:105858774-105880790 bp, + strand  Genetic Position: Chr11, 68.84 cM
Alliance: Acetm8.1Keb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163902
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsCre mediated recombination removed the neo cassette leaving the modified exon 20 intact (H993L and H997L). The predicted protein is expected to produce a C-terminally inactive form. (J:163902)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace Mutation:  54 strains or lines available
Notes
J:163902 and J:163454 selected for the single renin gene locus found in C57BL/6 mice instead of the duplicated locus found in 129 mice.
References
Original:  J:163902 Fuchs S, et al., Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension. 2008 Feb;51(2):267-74
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory