Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Itgaxtm1(HBEGF)Ktak
Name:	integrin alpha X; targeted mutation 1, Kiyoshi Takeda
MGI ID:	MGI:4822467
Synonyms:	CD11c-iDTR
Gene:	Itgax  Location: Chr7:127728719-127749829 bp, + strand  Genetic Position: Chr7, 69.98 cM
Alliance:	Itgaxtm1(HBEGF)Ktak page

Germline Transmission:	Earliest citation of germline transmission: J:162397
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Itgaxtm1(HBEGF)Ktak expresses 1 gene Knock-in expresses: Organism Expressed Gene Note monkey HBEGF   Mutation details: A construct, which contained (5' to 3') a adenoviral splice acceptor, loxP site, double poly-adenylation sequence, FRT flanked neo cassette, STOP cassette, loxP site, simian diphtheria toxin receptor cDNA, and poly-adenylation sequence, was inserted downstream of exon 1. Cre mediated removal of the STOP cassette is required to achieve expression of the simian cDNA. (J:162397)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgax Mutation:	73 strains or lines available

Original:	J:162397 Okuyama M, et al., A novel in vivo inducible dendritic cell ablation model in mice. Biochem Biophys Res Commun. 2010 Jul 2;397(3):559-63
All:	1 reference(s)