Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: CrygcM1Sbao Name: crystallin, gamma C; mutation 1, Shimin Bao MGI ID: MGI:4822430 Gene: Crygc  Location: Chr1:65110684-65112691 bp, - strand  Genetic Position: Chr1, 32.81 cM Alliance: CrygcM1Sbao page

Nuclear cataracts in CrygcM1Sbao/CrygcM1Sbao and CrygcM1Sbao/Crygc+ mice Show the 4 phenotype image(s) involving this allele.

Strain of Origin:

ICR

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: A spontaneous mutation arose in the F1 hybrids of BALB/cJ and ICR mice in which a single base pair was deleted from exon 3. This deletion results in novel amino acids 70 to 76 and a premature stop codon at amino acid 76. Sequence homology analysis confirmed that the mutation arose in the ICR strain. (J:163241) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crygc Mutation:	13 strains or lines available

Original:	J:163241 Zhao L, et al., A 1-bp deletion in the gammaC-crystallin leads to dominant cataracts in mice. Mamm Genome. 2010 Aug;21(7-8):361-9
All:	2 reference(s)