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Targeted Allele Detail
Symbol: Hoxb8tm1.1Mrc
Name: homeobox B8; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:2159735
Synonyms: Hoxb8lox
Gene: Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:73745
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsInsertion of a floxed neomycin resistance cassette into the second exon introduced a premature translation stop codon into the open reading frame. Pronuclear injection of pMC1-Cre into fertilized eggs carrying the Hoxb8tm1Mrc allele removed the neo cassette, leaving a single loxP site in the second exon. RT-PCR studies of brain detected a longer transcript produced by this allele than by the wild-type allele. (J:73745)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:  4 strains or lines available
Original:  J:73745 Greer JM, et al., Hoxb8 is required for normal grooming behavior in mice. Neuron. 2002 Jan 3;33(1):23-34
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory