Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxb8tm1Mrc
Name:	homeobox B8; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:2159734
Synonyms:	Hoxb8neo
Gene:	Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Alliance:	Hoxb8tm1Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:73745
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a floxed neomycin resistance cassette into the second exon introduced a 4 bp insertion into the first exon that was expected to cause a premature translation stop codon in the open reading frame. (J:73745)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:	8 strains or lines available

Original:	J:73745 Greer JM, et al., Hoxb8 is required for normal grooming behavior in mice. Neuron. 2002 Jan 3;33(1):23-34
All:	2 reference(s)