Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gata4tm2(Gata4)Wtp
Name:	GATA binding protein 4; targeted mutation 2, William T Pu
MGI ID:	MGI:3801683
Synonyms:	Gata4flap
Gene:	Gata4  Location: Chr14:63436371-63509141 bp, - strand  Genetic Position: Chr14, 33.24 cM
Alliance:	Gata4tm2(Gata4)Wtp page

Germline Transmission:	Earliest citation of germline transmission: J:137426
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inserted expressed sequence, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a floxed full-length Gata4 cDNA with a transcription STOP sequence followed by an alkaline phosphatase gene with a 3' frt site. An frt-flanked neo cassette used for selection purposes was removed by germ line, flp-mediated recombination. Cre mediated recombination is necessary to activate alkaline phospatase expression. (J:137426)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:	36 strains or lines available

Original:	J:137426 Zhou B, et al., Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3;454(7200):109-13
All:	5 reference(s)