Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Rbl1tm1.1Jsag
Name:	RB transcriptional corepressor like 1; targeted mutation 1.1, Julien Sage
MGI ID:	MGI:4818638
Synonyms:	p107E2F-1*
Gene:	Rbl1  Location: Chr2:156987813-157046454 bp, - strand  Genetic Position: Chr2, 78.05 cM
Alliance:	Rbl1tm1.1Jsag page

Germline Transmission:	Earliest citation of germline transmission: J:161509
Parent Cell Line:	V26.2 (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: A floxed neo resistance cassette was inserted within intron 1 on the BAC RP23-163J20. E2F binding site 1, TTTCgcgC, was mutated to TTTCaaaC. This BAC was then introduced by homologous recombination. The selection cassette was removed by cre mediated recombination. (J:161509)

Generation of the Rbl1tm1.1Jsag, Rbl1tm2.1Jsag, and Rbl1tm3.1Jsag alleles

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbl1 Mutation:	60 strains or lines available

Original:	J:161509 Burkhart DL, et al., Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet. 2010;6(6):e1001003
All:	1 reference(s)