Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sod2tm1(tetO-Sod2)Evbo
Name:	superoxide dismutase 2, mitochondrial; targeted mutation 1, Eva Bober
MGI ID:	MGI:4818481
Gene:	Sod2  Location: Chr17:13226726-13237006 bp, + strand  Genetic Position: Chr17, 8.75 cM
Alliance:	Sod2tm1(tetO-Sod2)Evbo page

Germline Transmission:	Earliest citation of germline transmission: J:162190
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inducible, Inserted expressed sequence, Null/knockout, Reporter) Inducer:    doxycycline/tetracycline Mutations:    Insertion, Intragenic deletion   Mutation details: The 5'UTR, exon 1, and exon 2 wwere replaced with a construct containing (5' to 3') an frt flanked neo cassette, tetracycline responsive (tetO/TRE) promoter, a myc-tagged Sod2 cDNA, and an IRES-EGFP. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast. (J:162190)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sod2 Mutation:	24 strains or lines available

Original:	J:162190 Loch T, et al., Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice. Cardiovasc Res. 2009 Jun 1;82(3):448-57
All:	2 reference(s)