Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxb8tm3.1(IRES-rtTA2*M2)Mrc
Name:	homeobox B8; targeted mutation 3.1, Mario R Capecchi
MGI ID:	MGI:4818439
Synonyms:	Hoxb8c
Gene:	Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Alliance:	Hoxb8tm3.1(IRES-rtTA2*M2)Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:162102
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Lox511 sites were inserted into the 5' and 3' UTRs of the Hoxb8 gene. An FRT-flanked neo selection cassette followed the 3' lox511 site. For temporal control of gene activation, an IRES-rtTA2M2 seqment was also introduced into the 3' UTR, along with an FRT-flanked neo selection cassette. The neo was subsequently removed by breeding with FLPe deleter animals. (J:162102)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:	8 strains or lines available

Original:	J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
All:	1 reference(s)