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Hoxb8tm2.1(cre)Mrc
Targeted Allele Detail
Nomenclature
Symbol: Hoxb8tm2.1(cre)Mrc
Name: homeobox B8; targeted mutation 2.1, Mario R Capecchi
MGI ID: MGI:4818426
Synonyms: C8cre, Hoxb8-ICre, Hoxb8-IRES-Cre
Gene: Hoxb8  Location: Chr11:96172731-96176141 bp, + strand  Genetic Position: Chr11, 59.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162102
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA 3.36 kb fragment consisting of cre recombinase preceded by an internal ribosomal entry site (IRES) and followed by an FRT-neo-FRT cassette was inserted into the 3' UTR of exon 2 of Hoxb8. The neomycin cassette was subsequently removed by breeding with FLPe deleter animals. (J:162102)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxb8     Summary of all recombinase alleles driven by Hoxb8.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxb8 Mutation:  4 strains or lines available
References
Original:  J:162102 Chen SK, et al., Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell. 2010 May 28;141(5):775-85
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory