Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pde11atm1Dgen
Name:	phosphodiesterase 11A; targeted mutation 1, Deltagen
MGI ID:	MGI:4462264
Gene:	Pde11a  Location: Chr2:75819485-76169118 bp, - strand  Genetic Position: Chr2, 44.8 cM
Alliance:	Pde11atm1Dgen page

Germline Transmission:	Earliest citation of germline transmission: J:160319
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A LacZ Neo cassette was inserted by homologous recombination to delete catalytic domain amino acids 693-717 (corresponding to bases 2123-2199). Deletion of mRNA in was confirmed by quantitative PCR, and deletion of protein was confirmed by Western blotting with multiple antibodies. (J:160319)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde11a Mutation:	48 strains or lines available

Original:	J:160319 Kelly MP, et al., Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8457-62
All:	8 reference(s)