Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tacc3tm1Jni
Name:	transforming, acidic coiled-coil containing protein 3; targeted mutation 1, James N Ihle
MGI ID:	MGI:2159700
Gene:	Tacc3  Location: Chr5:33815472-33836339 bp, + strand  Genetic Position: Chr5, 17.83 cM
Alliance:	Tacc3tm1Jni page

Germline Transmission:	Earliest citation of germline transmission: J:74762
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette is inserted into the third exon and is predicted to disrupt splicing. Failure to detect gene specific RNA and protein in fetal livers or total embryo extracts derived from homozygous animals confirmed the null nature of this allele. (J:74762)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tacc3 Mutation:	28 strains or lines available

Original:	J:74762 Piekorz RP, et al., The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis. EMBO J. 2002 Feb 15;21(4):653-64
All:	1 reference(s)