Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc6a4tm1(tTA)Cogr
Name:	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Cornelius Gross
MGI ID:	MGI:3800924
Synonyms:	Slc6a4tTA
Gene:	Slc6a4  Location: Chr11:76889429-76923166 bp, + strand  Genetic Position: Chr11, 46.18 cM
Alliance:	Slc6a4tm1(tTA)Cogr page

Germline Transmission:	Earliest citation of germline transmission: J:137439
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Transactivator) Mutation:    Insertion   Mutation details: A cassette containing the tetracycline trans-activator and a floxed neo were knocked into exon 2 at the translation initiation codon. In situ hybridization and autoradiography were used to confirm the absence of transcript and protein expression. (J:137439)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a4 Mutation:	51 strains or lines available

Original:	J:137439 Audero E, et al., Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science. 2008 Jul 4;321(5885):130-3
All:	3 reference(s)