Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Dact1tm1.3Bnrc
Name:	dishevelled-binding antagonist of beta-catenin 1; targeted mutation 1.3, Benjamin N R Cheyette
MGI ID:	MGI:4460656
Gene:	Dact1  Location: Chr12:71356658-71366881 bp, + strand  Genetic Position: Chr12, 29.39 cM
Alliance:	Dact1tm1.3Bnrc page

Germline Transmission:	Earliest citation of germline transmission: J:152701
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: An frt flanked neomycin resistance (neo) cassette was inserted upstream of exon 2 and exon 2 was floxed via homologous recombination. Cre-mediated recombination then removed exon 2 and Flp recombinase was used to delete the neomycin selection cassette. (J:152701)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dact1 Mutation:	21 strains or lines available

Original:	J:152701 Suriben R, et al., Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep;41(9):977-85
All:	2 reference(s)