Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zap70m6Hefl
Name:	zeta-chain (TCR) associated protein kinase; mutation 6, Heinrich Flaswinkel
MGI ID:	MGI:3800788
Synonyms:	TUM079, Zap70deltaT3
Gene:	Zap70  Location: Chr1:36800879-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70m6Hefl page

Strain of Origin:

C3HeB/FeJ

Allele Type:    Chemically induced (ENU) (Hypomorph) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced a transition of A to G leading to an amino acid substitution of glycine for glutamic acid at position 589 (E589G) in the kinase domain. Reduced protein expression was confirmed by western blot analysis on CD4+CD8+ thymocytes. This is a hypomorphic allele. (J:137446) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

Original:	J:137446 Jakob T, et al., Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. J Allergy Clin Immunol. 2008 Jan;121(1):179-184.e7
All:	1 reference(s)