Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Msh2tm3.1Rak
Name:	mutS homolog 2; targeted mutation 3.1, Raju Kucherlapati
MGI ID:	MGI:4460264
Synonyms:	Msh2G674D
Gene:	Msh2  Location: Chr17:87979960-88031141 bp, + strand  Genetic Position: Chr17, 57.87 cM
Alliance:	Msh2tm3.1Rak page

Germline Transmission:	Earliest citation of germline transmission: J:161577
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Hypomorph) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A floxed neo cassette was inserted upstream of modified exon 13 in which nucleotide substitutions (GGT to GAC) results in the amino acid substitution of aspartic acid for glycine at position 674 (G674D). Cre mediated recombination removed the neo cassette. (J:161577)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Msh2tm3.1Rak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:	95 strains or lines available

Original:	J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
All:	1 reference(s)