Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aviltm2(cre)Fawa
Name:	advillin; targeted mutation 2, Fan Wang
MGI ID:	MGI:4459942
Synonyms:	AdvillinCre
Gene:	Avil  Location: Chr10:126836578-126856863 bp, + strand  Genetic Position: Chr10, 74.48 cM, cytoband D3
Alliance:	Aviltm2(cre)Fawa page

Germline Transmission:	Earliest citation of germline transmission: J:160568
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Aviltm2(cre)Fawa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Avil (MGI:1333798)   Mutation details: A cre-IRES-EGFP was knocked into exon 2 of the Avil locus to achieve cre expression specifically within sensory neurons. Authors state that only male, not female, knockin animals are useful for sensory neuron-specific cre expression. The EGFP is nonfunctional. (J:160568, J:169302)

Activity:	Tissue activity of this recombinase allele
Driver:	Avil (mouse) Summary of all recombinase alleles driven by Avil. Comparative matrix view of recombinase activities Alliance mouse Avil gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Avil Mutation:	46 strains or lines available

Original:	J:160568 Zhou X, et al., Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9
All:	91 reference(s)