Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igf1tm2.1Nros
Name:	insulin-like growth factor 1; targeted mutation 1.1, Nadia Rosenthal
MGI ID:	MGI:4459505
Gene:	Igf1  Location: Chr10:87694127-87772904 bp, + strand  Genetic Position: Chr10, 43.7 cM
Alliance:	Igf1tm2.1Nros page

Germline Transmission:	Earliest citation of germline transmission: J:159167
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was floxed and a FRT-flanked PGK-neomycin-resistance cassette was inserted within intron 3 before the 3' loxP site. The floxed exon and neomycin selection cassette were removed by cre-mediated recombination. No IGF-1 transcripts were detected by RT-PCR of liver tissue. (J:159167)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:	27 strains or lines available

Original:	J:159167 Temmerman L, et al., Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels. Growth Horm IGF Res. 2010 Jun;20(3):255-63
All:	1 reference(s)