Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rettm3.1(Bcl2l1)Heno
Name:	ret proto-oncogene; targeted mutation 3.1, Hideki Enomoto
MGI ID:	MGI:4459031
Synonyms:	RetBcl-xL
Gene:	Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Rettm3.1(Bcl2l1)Heno page

Germline Transmission:	Earliest citation of germline transmission: J:159854
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: The cDNA and a floxed neo cassette was inserted into the first coding exon. Cre mediated recombination removed the neo cassette. Immunohistochemistry confirmed increased Bcl2l1 protein expression in enteric ganglia of heterozygous mice. (J:159854)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:	53 strains or lines available

Original:	J:159854 Uesaka T, et al., Neural precursor death is central to the pathogenesis of intestinal aganglionosis in Ret hypomorphic mice. J Neurosci. 2010 Apr 14;30(15):5211-8
All:	3 reference(s)