Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Portm3Ding
Name:	cytochrome p450 oxidoreductase; targeted mutation 3, Xinxin Ding
MGI ID:	MGI:4457492
Synonyms:	Cprr-CL
Gene:	Por  Location: Chr5:135698894-135764180 bp, + strand  Genetic Position: Chr5, 75.34 cM, cytoband G1
Alliance:	Portm3Ding page

Germline Transmission:	Earliest citation of germline transmission: J:159168
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted into intron 15. The reduction in protein expression was confirmed by western blot analysis on liver, kidney, brain, lung, and olfactory mucosa extracts. (J:159168)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Por Mutation:	78 strains or lines available

Original:	J:159168 Wei Y, et al., Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J Pharmacol Exp Ther. 2010 Jul;334(1):69-77
All:	2 reference(s)