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Sp7tm1Crm
Targeted Allele Detail
Nomenclature
Symbol: Sp7tm1Crm
Name: Sp7 transcription factor 7; targeted mutation 1, Benoit de Crombrugghe
MGI ID: MGI:2159411
Synonyms: Osterix-, Osx-
Gene: Sp7  Location: Chr15:102356603-102367035 bp, - strand  Genetic Position: Chr15, 57.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74344
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 2 is deleted and a LacZ reporter gene is inserted into the locus. A lack of gene expression was confirmed using Northern analysis. (J:74344)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp7 Mutation:  7 strains or lines available
References
Original:  J:74344 Nakashima K, et al., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2021
MGI 6.16
The Jackson Laboratory