Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Pdha1tm1e(EUCOMM)Wtsi
Name:	pyruvate dehydrogenase E1 alpha 1; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID:	MGI:4456065
Gene:	Pdha1  Location: ChrX:158905205-158921409 bp, - strand  Genetic Position: ChrX, 73.95 cM, cytoband F3-F4
IMPC:	Pdha1 gene page

Mutant Cell Lines:	EPD0556_2_B04, EPD0556_2_B05, EPD0556_2_G04, EPD0556_2_G05, EPD0556_2_H04
Germline Transmission:	Unknown
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	EUCOMM

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_gt0   Mutation details: The L1L2_gt0 cassette was inserted at position 158913657 of Chromosome X upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Pdha1 Mutation:	23 strains or lines available

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	2 reference(s)