Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd226tm1.1Cln
Name:	CD226 antigen; targeted mutation 1.1, Marco Colonna
MGI ID:	MGI:4454325
Synonyms:	DNAM-1-
Gene:	Cd226  Location: Chr18:89195091-89290353 bp, + strand  Genetic Position: Chr18, 59.05 cM
Alliance:	Cd226tm1.1Cln page

Germline Transmission:	Earliest citation of germline transmission: J:159749
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons two and three, encoding the start site and first 129 amino acids, were replaced by a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:159749)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd226 Mutation:	35 strains or lines available

Original:	J:159749 Gilfillan S, et al., DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med. 2008 Dec 22;205(13):2965-73
All:	17 reference(s)