Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Airetm3(cre)Mmat
Name:	autoimmune regulator; targeted mutation 3, Mitsuru Matsumoto
MGI ID:	MGI:4454265
Synonyms:	Aire/Cre KI
Gene:	Aire  Location: Chr10:77865856-77879444 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Airetm3(cre)Mmat page

Germline Transmission:	Earliest citation of germline transmission: J:160217
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Airetm3(cre)Mmat expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aire (MGI:1338803)   Mutation details: A cre recombinase-floxed neomycin resistance cassette was inserted into exon 1 of the Aire gene, such that expression was under control of the endogenous Aire promoter. The floxed neo cassette was spontaneously deleted, likely as a result of autonomous expression of cre from the Aire locus during early embryogenesis and/or spermatogenesis. (J:160217)

Generation of the Airetm3(cre)Mmat allele

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (mouse) Summary of all recombinase alleles driven by Aire. Comparative matrix view of recombinase activities Alliance mouse Aire gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aire Mutation:	52 strains or lines available

Original:	J:160217 Nishikawa Y, et al., Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med. 2010 May 10;207(5):963-71
All:	1 reference(s)