Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rr94tm3.1Litt
Name:	regulatory region 94; targeted mutation 3.1, Dan R Littman
MGI ID:	MGI:4452050
Synonyms:	Cd4E4pFL, Cd4tm3.1Litt, E4PF
Gene:	Rr94  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance:	Rr94tm3.1Litt page

Germline Transmission:	Earliest citation of germline transmission: J:158962
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, Modified regulatory region, No functional change) Mutation:    Insertion   Mutation details: Proximal enhancer E4p upstream of Cd4 exon 1 was flanked by a loxP site and a floxed neomycin resistance gene cassette. Cre-mediated recombination removed the neo cassette leaving the enhancer floxed. (J:158962)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr94 Mutation:	0 strains or lines available

Original:	J:158962 Chong MM, et al., Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010 Apr 1;24(7):659-69
All:	2 reference(s)