Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mapttm2(RHOA*)Klt
Name:	microtubule-associated protein tau; targeted mutation 2, Kerry Lee Tucker
MGI ID:	MGI:4442944
Gene:	Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapttm2(RHOA*)Klt page

Germline Transmission:	Earliest citation of germline transmission: J:159220
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, Dominant negative, Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mapttm2(RHOA*)Klt expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human RHOA (387) Rhoa  (MGI:1096342)   Mutation details: Exon 1 was replaced with a vector containing a floxed STOP cassette, HA-tagged human cDNA with a nucleotide substitution resulting in the amino acid substitution of threonine with asparagine at position 19, and a neo cassette. Cre mediated recombination is required for the expression of a dominant-negative form. (J:159220)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:	428 strains or lines available

Original:	J:159220 Sanno H, et al., Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density. J Neurosci. 2010 Mar 24;30(12):4221-31
All:	1 reference(s)