Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trp73tm2Mak
Name:	transformation related protein 73; targeted mutation 2, Tak Mak
MGI ID:	MGI:4442798
Synonyms:	deltaNp73-
Gene:	Trp73  Location: Chr4:154140706-154224332 bp, - strand  Genetic Position: Chr4, 83.79 cM
Alliance:	Trp73tm2Mak page

Germline Transmission:	Earliest citation of germline transmission: J:157905
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s), Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3' was replaced with a neo cassette by homologous recombination. This targets the delta Np73 isoforms but not TAp73 isoforms. The loss of Np73 isoform mRNA expression was confirmed by quantitative RT-PCR in MEFs and western blot analysis of lung tissue confirmed loss of isoform specific protein expression. Quantitative RT-PCR of liver, testis, and lung confirmed the retention of TAp73 isoform mRNA expression. (J:157905)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trp73 Mutation:	42 strains or lines available

Original:	J:157905 Wilhelm MT, et al., Isoform-specific p73 knockout mice reveal a novel role for {Delta}Np73 in the DNA damage response pathway. Genes Dev. 2010 Mar 15;24(6):549-60
All:	3 reference(s)