Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax3tm2.1Joe
Name:	paired box 3; targeted mutation 2.1, Jonathan A Epstein
MGI ID:	MGI:4442463
Synonyms:	Pax3NCE
Gene:	Pax3  Location: Chr1:78077904-78173771 bp, - strand  Genetic Position: Chr1, 39.79 cM
Alliance:	Pax3tm2.1Joe page

Germline Transmission:	Earliest citation of germline transmission: J:159124
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: A 674 bp neural crest enhancer region within the upstream genomic region was replaced by a flowed PGK-neo cassette. The PGK-neo cassette was removed by Cre-mediated recombination. Immunohistochemistry of E11.5 homozygous embryos revealed apparently normal level and distribution of the protein compared to wild-type littermates. (J:159124)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax3 Mutation:	50 strains or lines available

Original:	J:159124 Degenhardt KR, et al., Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15;339(2):519-27
All:	1 reference(s)