Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptprcltng
Name:	protein tyrosine phosphatase receptor type C; lightning
MGI ID:	MGI:4441612
Synonyms:	PtprcL
Gene:	Ptprc  Location: Chr1:137990599-138103446 bp, - strand  Genetic Position: Chr1, 60.73 cM
Alliance:	Ptprcltng page

Strain of Origin:	C57BL/6
Project Collection:	APF ENU Mutagenesis

Allele Type:    Chemically induced (ENU) Mutation:    Nucleotide substitutions   Mutation details: ENU induced at T to C transition that results in the amino acid substitution of serine for phenylalanine at position 503 (F503S). Flow cytometry confirmed that protein half-life is reduced. (J:158876)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:	188 strains or lines available

Original:	J:158876 Zikherman J, et al., CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26;32(3):342-54
All:	5 reference(s)