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Nr1h4tm1.1Auw
Targeted Allele Detail
Summary
Symbol: Nr1h4tm1.1Auw
Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.1, Johan Auwerx
MGI ID: MGI:4437613
Gene: Nr1h4  Location: Chr10:89290096-89369447 bp, - strand  Genetic Position: Chr10, 44.98 cM
Alliance: Nr1h4tm1.1Auw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157882
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 6 was floxed. An frt flanked neo cassette used for selection was removed by flp mediated recombination. (J:157882)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:  43 strains or lines available
References
Original:  J:157882 Milona A, et al., The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G151-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory