Rettm2(cre/ERT2)Ddg
Targeted Allele Detail
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Symbol: |
Rettm2(cre/ERT2)Ddg |
Name: |
ret proto-oncogene; targeted mutation 2, David D Ginty |
MGI ID: |
MGI:4437245 |
Synonyms: |
RetCreER, RetCreERT2, Ret-CreERT2, RetERT2 |
Gene: |
Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
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Alliance: |
Rettm2(cre/ERT2)Ddg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:157722
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Rettm2(cre/ERT2)Ddg expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Ret (MGI:97902) |
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Mutation details: The first exon of the Ret gene was targeted for homologous recombination. A sequence encoding inducible cre/ERT2, followed by a loxP-flanked AC-Cre Tn5-neo self-excising cassette, was targeted to exon 1 of Ret in ES cells. Following excision of the floxed neo cassette, a line of knockin mice expressing cre/ERT2 was generated. Spatial and temporal expression patterns of the inducible cre recapitulated Ret expression.
(J:157722)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Ret
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ret Mutation: |
53 strains or lines available
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Original: |
J:157722 Luo W, et al., Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. Neuron. 2009 Dec 24;64(6):841-56 |
All: |
35 reference(s) |
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