Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ptprotm1a(EUCOMM)Hmgu
Name:	protein tyrosine phosphatase receptor type O; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4435999
Gene:	Ptpro  Location: Chr6:137229317-137440231 bp, + strand  Genetic Position: Chr6, 66.75 cM
IMPC:	Ptpro gene page

Mutant Cell Lines:	HEPD0542_6_A02, HEPD0542_6_B02, HEPD0542_6_B04
Germline Transmission:	Unknown
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Pgk_P   Mutation details: The L1L2_Pgk_P cassette was inserted at position 137362678 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 137363617. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Ptpro Mutation:	122 strains or lines available

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	1 reference(s)