Rrm2btm1e(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Rrm2btm1e(EUCOMM)Hmgu |
Name: |
ribonucleotide reductase M2 B (TP53 inducible); targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:4435111 |
Gene: |
Rrm2b Location: Chr15:37924196-37961562 bp, - strand Genetic Position: Chr15, 15.1 cM
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IMPC: |
Rrm2b gene page |
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Mutant Cell Lines: |
HEPD0549_7_A09, HEPD0549_7_A11, HEPD0549_7_B11, HEPD0549_7_C09, HEPD0549_7_C11, HEPD0549_7_D10, HEPD0549_7_D12, HEPD0549_7_E10, HEPD0549_7_E11, HEPD0549_7_E12, HEPD0549_7_F10, HEPD0549_7_F11, HEPD0549_7_F12, HEPD0549_7_G10, HEPD0549_7_G11, HEPD0549_7_G12, HEPD0549_7_H09 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 37945866 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:157065)
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Original: |
J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015; |
All: |
1 reference(s) |
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