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Runx1tm2Buch
Targeted Allele Detail
Summary
Symbol: Runx1tm2Buch
Name: runt related transcription factor 1; targeted mutation 2, Frank Buchholz
MGI ID: MGI:3798051
Synonyms: AML1f
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm2Buch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105709
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin targeting cassette was placed downstream of exon 5 and a loxP site was placed upstream of exon 5. Correct targeting was confirmed through genomic PCR. (J:105709)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  35 strains or lines available
References
Original:  J:105709 Putz G, et al., AML1 deletion in adult mice causes splenomegaly and lymphomas. Oncogene. 2006 Feb 9;25(6):929-39
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory