Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Slx4tm1a(EUCOMM)Wtsi
Name:	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae); targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4432843
Synonyms:	Btbd12f3, Btbd12tm1a(EUCOMM)Wtsi, Fancp-
Gene:	Slx4  Location: Chr16:3796969-3821634 bp, - strand  Genetic Position: Chr16, 2.34 cM
Alliance:	Slx4tm1a(EUCOMM)Wtsi page
IMPC:	Slx4 gene page

Mutant Cell Lines:	EPD0028_7_A07, EPD0028_7_A08, EPD0028_7_A09, EPD0028_7_E07, EPD0028_7_E09, EPD0028_7_F08, EPD0028_7_H09
Germline Transmission:	Earliest citation of germline transmission: J:168567
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_gt1   Mutation details: The L1L2_gt1 cassette was inserted at position 3813295 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 3814186. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:168567, J:173534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Slx4 Mutation:	57 strains or lines available

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	10 reference(s)