Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc20a2tm1a(EUCOMM)Wtsi
Name:	solute carrier family 20, member 2; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4431725
Gene:	Slc20a2  Location: Chr8:22966804-23059628 bp, + strand  Genetic Position: Chr8, 11.42 cM
Alliance:	Slc20a2tm1a(EUCOMM)Wtsi page
IMPC:	Slc20a2 gene page

Mutant Cell Lines:	EPD0243_1_A06, EPD0243_1_C06, EPD0243_1_C08, EPD0243_1_D05, EPD0243_1_F05, EPD0243_1_F07, EPD0243_1_G08
Germline Transmission:	Earliest citation of germline transmission: J:175295
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Pgk_P   Mutation details: The L1L2_Pgk_P cassette was inserted at position 23029908 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 23030738. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Slc20a2 Mutation:	103 strains or lines available

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	22 reference(s)