Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	C1qatm1.1Tenn
Name:	complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1.1, Andrea J Tenner
MGI ID:	MGI:3796996
Gene:	C1qa  Location: Chr4:136623228-136626114 bp, - strand  Genetic Position: Chr4, 69.05 cM
Alliance:	C1qatm1.1Tenn page

Germline Transmission:	Earliest citation of germline transmission: J:136269
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Humanized sequence) Mutation:    Nucleotide substitutions   Mutation details: Four amino acids within the exon 1 of the mouse sequence were converted to the corresponding human sequence and introduced by targeted homologous recombination with loxP flanked neo cassette place in intron 1. The neo cassette was removed either by crossing with deleter cre expressing strain or by transient transfection with cre. (J:136269)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any C1qa Mutation:	22 strains or lines available

Original:	J:136269 Li M, et al., Development of a humanized C1q A chain knock-in mouse: Assessment of antibody independent ss-amyloid induced complement activation. Mol Immunol. 2008 Jun;45(11):3244-52
All:	2 reference(s)