Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 9, Klaus Rajewsky
MGI ID:	MGI:4430551
Synonyms:	LSL-Rac1G12V, R26Stop flox RACDA, R26Stop-flox-RACDA, R26StopFLRACDA, RacG12V, RacV12
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky page

Germline Transmission:	Earliest citation of germline transmission: J:157297
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Rac1 (MGI:97845)   Mutation details: A targeting vector designed with (from 5' to 3') a splice acceptor site, a loxP-flanked Neo-STOP cassette, a cDNA sequence encoding RACDA (RacG12V; a mutant form of Rac1 rendered constitutively active by a glycine->valine substitution at amino acid 12]), an frt-flanked internal ribosomal entry site-enhanced green fluorescent protein cassette (IRES-EGFP), and bovine polyadenylation signal. This transgene construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. (J:157297)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:157297 Srinivasan L, et al., PI3 kinase signals BCR-dependent mature B cell survival. Cell. 2009 Oct 30;139(3):573-86
All:	7 reference(s)