Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rfx6tm1.1(EGFP/cre)Mger
Name:	regulatory factor X, 6; targeted mutation 1.1, Michael S German
MGI ID:	MGI:4429702
Synonyms:	Rfx6eGFPcre
Gene:	Rfx6  Location: Chr10:51553856-51606525 bp, + strand  Genetic Position: Chr10, 25.74 cM
Alliance:	Rfx6tm1.1(EGFP/cre)Mger page

Germline Transmission:	Earliest citation of germline transmission: J:156925
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Rfx6tm1.1(EGFP/cre)Mger expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Rfx6 (MGI:2445208)   Mutation details: Recombineering methods were used to modify a BAC containing the Rfx6 gene and generate the targeting construct. Homologous recombination in ES cells resulted in the first 5 exons being replaced by and EFGP/cre fusion gene followed by an FRT-flanked neo cassette. The neo was subsequently removed by crossing mice carrying the disrupted allele with Actb-Flp mice. (J:156925)

Activity:	Tissue activity of this recombinase allele
Driver:	Rfx6 (mouse) Summary of all recombinase alleles driven by Rfx6. Alliance mouse Rfx6 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rfx6 Mutation:	52 strains or lines available

Original:	J:156925 Smith SB, et al., Rfx6 directs islet formation and insulin production in mice and humans. Nature. 2010 Feb 11;463(7282):775-80
All:	5 reference(s)