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Clocktm1Rep
Targeted Allele Detail
Summary
Symbol: Clocktm1Rep
Name: clock circadian regulator; targeted mutation 1, Steven M Reppert
MGI ID: MGI:4421507
Synonyms: Clockflox, Clocktm1Drw
Gene: Clock  Location: Chr5:76357715-76452639 bp, - strand  Genetic Position: Chr5, 40.63 cM
Alliance: Clocktm1Rep page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109634
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette containing neomycin resistance and thymidine kinase genes was inserted upstream of exon 5 and a loxp site was inserted downstream of exon 6. Transient cre expression in ES cells removed the neo cassette leaving exons 5 and 6 floxed (J:109634)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clock Mutation:  101 strains or lines available
References
Original:  J:109634 Debruyne JP, et al., A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron. 2006 May 4;50(3):465-77
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory