Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atoh1tm6.1Hzo
Name:	atonal bHLH transcription factor 1; targeted mutation 6.1, Huda Y Zoghbi
MGI ID:	MGI:4420925
Synonyms:	Atoh1flag
Gene:	Atoh1  Location: Chr6:64706109-64708229 bp, + strand  Genetic Position: Chr6, 30.03 cM
Alliance:	Atoh1tm6.1Hzo page

Germline Transmission:	Earliest citation of germline transmission: J:155047
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Inserted expressed sequence, No functional change, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A cDNA encoding for a version of the gene with three C-terminal FLAG tags and an FRT-NEO-FRT selection cassette was inserted, replacing the entire coding sequence. The selection cassette was then removed by flp mediated recombination. Expression of the tagged protein in the cerebellum but not the cortex was confirmed by chromatin immunoprecipitation analysis. (J:155047)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

21 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atoh1 Mutation:	36 strains or lines available

Original:	J:155047 Flora A, et al., Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science. 2009 Dec 4;326(5958):1424-7
All:	5 reference(s)