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Tg(tetO-LRRK2*)D10Cai
Transgene Detail
Summary
Symbol: Tg(tetO-LRRK2*)D10Cai
Name: transgene insertion D10, Huaibin Cai
MGI ID: MGI:4420818
Synonyms: tetO-KD
Transgene: Tg(tetO-LRRK2*)D10Cai  Location: unknown  
Alliance: Tg(tetO-LRRK2*)D10Cai page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation detailsA transgenic vector was generated encoding the C-terminal hemagglutinin (HA)-tagged human LRRK2 gene with complete deletion of the kinase domain (deletion of residues 1187 to 2102) under control of a tetO promoter. The construct was microinjected into fertilized oocytes. Line D10 was analyzed further. (J:156512)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:156512 Lin X, et al., Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 2009 Dec 24;64(6):807-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory