Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Pnliprp2tm1a(KOMP)Wtsi
Name:	pancreatic lipase-related protein 2; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4420097
Gene:	Pnliprp2  Location: Chr19:58748155-58765966 bp, + strand  Genetic Position: Chr19, 54.5 cM, cytoband D3
Alliance:	Pnliprp2tm1a(KOMP)Wtsi page
IMPC:	Pnliprp2 gene page

Mutant Cell Lines:	EPD0394_2_A09, EPD0394_2_B12, EPD0878_4_A11, EPD0878_4_C12, EPD0878_4_D10
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 58751254 of Chromosome 19 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 58752113. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Pnliprp2 Mutation:	30 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	3 reference(s)