Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Enamtm1.1Jcch Name: enamelin; targeted mutation 1.1, Jan C C Hu MGI ID: MGI:3796583 Synonyms: EnamlacZ Gene: Enam  Location: Chr5:88635834-88653908 bp, + strand  Genetic Position: Chr5, 43.66 cM, cytoband E2 Alliance: Enamtm1.1Jcch page

Tooth abnormalities in Enamtm1.1Jcch/Enam+ and Enamtm1.1Jcch/Enamtm1.1Jcch mice at 7 weeks of age Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:136524
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 3 through exon 7 was replaced with a lacZ and floxed neo cassette. The neo cassette was subsequently removed by crossing targeted mice with transgenic mice expressing cre recombinase in the germline. The absence of protein product was confirmed by western blot analysis on enamel extracts. This is a reporter allele and a null allele. (J:136524)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Enam Mutation:	71 strains or lines available

Original:	J:136524 Hu JC, et al., Enamel defects and ameloblast-specific expression in Enam knock-out/lacz knock-in mice. J Biol Chem. 2008 Apr 18;283(16):10858-71
All:	7 reference(s)