Gata5tm1Eem
Targeted Allele Detail
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Symbol: |
Gata5tm1Eem |
Name: |
GATA binding protein 5; targeted mutation 1, Edward E Morrisey |
MGI ID: |
MGI:4417873 |
Synonyms: |
Gata5tm2Eem |
Gene: |
Gata5 Location: Chr2:179966926-179976492 bp, - strand Genetic Position: Chr2, 102.85 cM
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Alliance: |
Gata5tm1Eem page
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Ventriclular abnormalities in Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5tm1Eem and Gata4tm1Jml/Gata4+ Gata5tm1Eem/Gata5+ mice
Show the 3 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: This mutant allele retains the 5' region of the gene through the first 20 base pairs of exon 2, which encode the first zinc finger of the protein. A lacZ-PGK-neo cassette has replaced the remaining 3' portion of exon2 and all of intron 2 and exon3, including the second and third zinc finger coding sequences. Neither RT-qPCR analysis nor in situ hybridization to E10.5 embryos detected any transcripts.
(J:155855)
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Generation of the Gata5tm1Eem allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gata5 Mutation: |
17 strains or lines available
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Original: |
J:155855 Singh MK, et al., Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. J Biol Chem. 2010 Jan 15;285(3):1765-72 |
All: |
2 reference(s) |
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