Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd79atm2(cre/Esr1*)Reth
Name:	CD79A antigen (immunoglobulin-associated alpha); targeted mutation 2, Michael Reth
MGI ID:	MGI:4414764
Synonyms:	mb1-MerCreMEr
Gene:	Cd79a  Location: Chr7:24596922-24601283 bp, + strand  Genetic Position: Chr7, 13.49 cM
Alliance:	Cd79atm2(cre/Esr1*)Reth page

Germline Transmission:	Earliest citation of germline transmission: J:155473
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Cd79atm2(cre/Esr1*)Reth expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cd79a (MGI:101774)   Mutation details: The MerCreMer construct, which contains two mutated mouse estrogen receptors flanking the cre coding region, was knocked into the locus. This construct sequesters the cre fusion in the cytoplasm until estrogen or a derivative is administered. (J:155473)

Activity:	Tissue activity of this recombinase allele
Driver:	Cd79a (mouse) Summary of all recombinase alleles driven by Cd79a. Alliance mouse Cd79a gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd79a Mutation:	22 strains or lines available

Original:	J:155473 Duber S, et al., Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood. 2009 Dec 3;114(24):4960-7
All:	2 reference(s)