Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mirc3tm1Tyj
Name:	microRNA cluster 3, including Mir25 through Mir106b; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:3795503
Synonyms:	miR-106b~25deltaneo
Gene:	Mirc3  Location: Chr5:138163583-138164080 bp  Genetic Position: Chr5, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:134861
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Intergenic deletion   Mutation details: The Mir106b, Mir93, and Mir25 genes were replaced by an Frt-flanked neomycin cassette. No homozygous mutants are obtained if the neomycin is left in place, but Flp-mediated deletion of neo produces phenotypically normal homozygous mice. Since the Mirn106b-25 cluster resides in the 13th intron of the Mcm7 gene, these results suggest that the neomycin cassette interferes with expression of Mcm7. (J:134861)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mirc3 Mutation:	1 strain or line available

Original:	J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
All:	1 reference(s)